Plasma histamine levels following atracurium.

  title={Plasma histamine levels following atracurium.},
  author={P K Barnes and N de Renzy-Martin and Veronica J. Thomas and John Watkins},
  volume={41 8},
Plasma histamine levels were determined in 41 patients, 1.5 and 4 minutes after the intravenous administration of 0.6 mg/kg of atracurium. Clinical features of histamine release were sought at the time of blood sampling. Sixteen patients had elevation of plasma histamine 2.6 (SD 1.2) ng/ml 1.5 minutes after the injection of atracurium. Plasma histamine had returned to control levels at 4 minutes. There was a poor correlation between plasma histamine levels and the clinical manifestations… CONTINUE READING