Plasma guanidino compounds are altered by oral creatine supplementation in healthy humans.

@article{Derave2004PlasmaGC,
  title={Plasma guanidino compounds are altered by oral creatine supplementation in healthy humans.},
  author={Wim Derave and Bart Marescau and Els Vanden Eede and Bert O. Eijnde and Peter Paul De Deyn and Peter Hespel},
  journal={Journal of applied physiology},
  year={2004},
  volume={97 3},
  pages={
          852-7
        }
}
Although creatine is one of the most widely used nutritional supplements for athletes as well as for patients with neuromuscular disorders, the effects of oral creatine supplementation on endogenous creatine synthesis in humans remains largely unexplored. The aim of the present study was to investigate the metabolic consequences of a frequently used, long-term creatine ingestion protocol on the circulating creatine synthesis precursor molecules, guanidinoacetate and arginine, and their related… 
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The findings indicate that whereas creatine supplementation downregulates endogenous creatine synthesis, this may not on average lower plasma tHcys in humans, but did decrease in those participants who experienced a decline in plasma guanidinoacetate while receiving creatine plus folic acid supplementation.
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It is indicated that hepatocytes are incapable of the entire synthesis of creatine but are capable of producing it from GAA, which illustrates the interplay between the dietary provision of creatine and its de novo synthesis and point to the crucial role of renal AGAT expression in regulating creatine synthesis in the rat.
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This is the first detailed analysis of creatine kinetics and the effects of creatine supplement in healthy young men and women and there was a significant decrease in the rate of appearance of glycine, suggesting a decrease in de-novo synthesis.
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