Plasma glutamate and glycine levels in patients with amyotrophic lateral sclerosis: the effect of riluzole treatment.

@article{Andreadou2008PlasmaGA,
  title={Plasma glutamate and glycine levels in patients with amyotrophic lateral sclerosis: the effect of riluzole treatment.},
  author={Elisabeth Andreadou and E Kapaki and Panagiotis Kokotis and G P Paraskevas and Nikolaos Katsaros and Georgia Libitaki and Vassilios Panagiotis Zis and Constantinos Sfagos and Demetrios C Vassilopoulos},
  journal={Clinical neurology and neurosurgery},
  year={2008},
  volume={110 3},
  pages={222-6}
}
OBJECTIVES Defective glutamate (glu) metabolism and excitotoxicity have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Moreover, glycine (gly) has been shown to potentiate excitatory transmission. The "antiglutamatergic" agent riluzole has been shown to prolong survival in ALS. The aim of the study was to investigate a possible effect of riluzole on plasma glu and gly levels, correlating with clinical response to treatment. PATIENTS AND METHODS Plasma… CONTINUE READING
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