Plasma glucose lowering effect of spartein sulphate infusion in non-insulin dependent (Type 2) diabetic subjects

@article{Paolisso1988PlasmaGL,
  title={Plasma glucose lowering effect of spartein sulphate infusion in non-insulin dependent (Type 2) diabetic subjects},
  author={Guiseppe Paolisso and Saverio Sgambato and Nicola Passariello and Giancarlo Pizza and Roberto Torella and Paola Tesauro and Michele Varricchio and F D'onofrio},
  journal={European Journal of Clinical Pharmacology},
  year={1988},
  volume={34},
  pages={227-232}
}
Sparteine sulphate, given i.v. as a bolus of 15 mg/ml plus 90 mg in 0.9% NaCl 100 ml over 60 min, increases plasma insulin and decreases plasma glucose and adrenaline in non-insulin dependent (Type II) diabetic subjects. The hypoglycaemic effect was also evident in the presence of a high plasma glucose level produced by Biostator changing glucose infusion from 20.2±2.8 to 26.4±4.2 mg · kg−1 · min−1 (p<0.01), and it was potentiated by simultaneous infusion of arginine. No additional effect of… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 14 references

Effects of sparteine sulfate on glucagon secretion in insulin dependent (type-1) diabetic subjects.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme • 1987
View 1 Excerpt

Effect of sparteine sulfate on insulin secretion in normal men.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme • 1986
View 2 Excerpts

Sparteine sulphate increase insulin re- lease by decreasing the K + permeability of the/3-cell mem- brane

G Paolisso, M Nenquin, +3 authors JC Henquin
Biochem Pharmacol • 1985
View 2 Excerpts

The effects of cesium chloride on insulin release, inoic flux and membrane potential in pancreatic r-cell

G Paolisso, M Nenquin, HP Meissner, JC Henquin
Biochem Bio- phys Acta • 1985
View 1 Excerpt

Opposite effects of tolbuta- mide and diazoxide on 86Rb flux and membrane potential in pancreatic r-cell

JC Henquin, HP Meissner
Biochem Phamaacol • 1982
View 1 Excerpt

Glucose clamp using the Biostator GCIIS Horm Me - tab Res

CA Verdonk, RA Rizza, RE Westland, RL Nelson, JE Gerich
1980

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