Plasma glial fibrillary acidic protein levels in children with sickle cell disease

  title={Plasma glial fibrillary acidic protein levels in children with sickle cell disease},
  author={W. Savage and Emily A Barron-Casella and Zongming Fu and Pratima Dulloor and Lisa M. Williams and B. Crain and D. White and J. Jennings and J. V. Van Eyk and M. DeBaun and Allen E. Everett and J. Casella},
  journal={American Journal of Hematology},
  • W. Savage, Emily A Barron-Casella, +9 authors J. Casella
  • Published 2011
  • Medicine
  • American Journal of Hematology
  • To determine if glial fibrillary acidic protein (GFAP) is associated with brain injury in children with sickle cell disease (SCD), we measured plasma GFAP among cross-sectional groups of unselected children with SCD, subsets of children with SCD and normal brain MRI or MRI evidence of cerebral infarct, healthy pediatric controls, and adults with brain injury. Children with SCD had higher plasma GFAP than healthy pediatric controls (mean concentrations 0.14 ± 0.37 vs. 0.07 ± 0.08 ng/mL; P 5 0… CONTINUE READING
    23 Citations

    Topics from this paper

    Glial fibrillary acidic protein as a biomarker for brain injury in neonatal CHD
    • 7
    Proteomic and biomarker studies and neurological complications of pediatric sickle cell disease
    • 9
    Association of nadir oxygen delivery on cardiopulmonary bypass with serum glial fibrillary acid protein levels in paediatric heart surgery patients.
    • 10
    • PDF
    Acute silent cerebral ischemic events in children with sickle cell anemia.
    • 46
    • PDF
    Parent education and biologic factors influence on cognition in sickle cell anemia
    • 95
    • PDF


    Glial fibrillary acidic protein as a brain injury biomarker in children undergoing extracorporeal membrane oxygenation*
    • M. Bembea, W. Savage, +4 authors Allen E. Everett
    • Medicine
    • Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
    • 2011
    • 73
    Cognitive functioning and brain magnetic resonance imaging in children with sickle cell disease
    • 348
    • Highly Influential
    Increased serum-GFAP in patients with severe traumatic brain injury is related to outcome
    • 169