Plasma glial fibrillary acidic protein levels in children with sickle cell disease
@article{Savage2011PlasmaGF, title={Plasma glial fibrillary acidic protein levels in children with sickle cell disease}, author={W. Savage and Emily A Barron-Casella and Zongming Fu and Pratima Dulloor and Lisa M. Williams and B. Crain and D. White and J. Jennings and J. V. Van Eyk and M. DeBaun and Allen E. Everett and J. Casella}, journal={American Journal of Hematology}, year={2011}, volume={86} }
To determine if glial fibrillary acidic protein (GFAP) is associated with brain injury in children with sickle cell disease (SCD), we measured plasma GFAP among cross-sectional groups of unselected children with SCD, subsets of children with SCD and normal brain MRI or MRI evidence of cerebral infarct, healthy pediatric controls, and adults with brain injury. Children with SCD had higher plasma GFAP than healthy pediatric controls (mean concentrations 0.14 ± 0.37 vs. 0.07 ± 0.08 ng/mL; P 5 0… CONTINUE READING
Supplemental Clinical Trials
Interventional Clinical Trial
The goal of this study is to determine the effectiveness of blood transfusion therapy for
prevention of silent cerebral infarct (stroke) in children with sickle cell anemia.
Conditions | Sickle Cell Anemia, Stroke |
---|---|
Intervention | Procedure |
Topics from this paper
23 Citations
Glial fibrillary acidic protein as a biomarker for brain injury in neonatal CHD
- Medicine
- Cardiology in the Young
- 2016
- 7
Glial fibrillary acidic protein in children with congenital heart disease undergoing cardiopulmonary bypass
- Medicine
- Cardiology in the Young
- 2013
- 16
Brain‐derived neurotrophic factor levels in pediatric sickle cell disease
- Medicine
- Pediatric blood & cancer
- 2019
- 1
Proteomic and biomarker studies and neurological complications of pediatric sickle cell disease
- Medicine
- Proteomics. Clinical applications
- 2014
- 9
Association of nadir oxygen delivery on cardiopulmonary bypass with serum glial fibrillary acid protein levels in paediatric heart surgery patients.
- Medicine
- Interactive cardiovascular and thoracic surgery
- 2016
- 10
- PDF
Acute silent cerebral ischemic events in children with sickle cell anemia.
- Medicine
- JAMA neurology
- 2013
- 46
- PDF
Thrombospondin‐1 and L‐selectin are associated with silent cerebral infarct in children with sickle cell anaemia
- Medicine
- British journal of haematology
- 2013
- 9
Pre- and post-operative plasma glial fibrillary acidic protein levels in patients with newly diagnosed gliomas
- Biology, Medicine
- Journal of Neuro-Oncology
- 2012
- 31
Parent education and biologic factors influence on cognition in sickle cell anemia
- Medicine
- American journal of hematology
- 2014
- 95
- PDF
References
SHOWING 1-10 OF 30 REFERENCES
Glial fibrillary acidic protein as a brain injury biomarker in children undergoing extracorporeal membrane oxygenation*
- Medicine
- Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
- 2011
- 73
Serum glial fibrillary acidic protein is a highly specific biomarker for traumatic brain injury in humans compared with S-100B and neuron-specific enolase.
- Medicine
- The Journal of trauma
- 2010
- 147
Release of glial fibrillary acidic protein is related to the neurovascular status in acute ischemic stroke
- Medicine
- European journal of neurology
- 2006
- 58
Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury
- Medicine
- Neurology
- 2004
- 363
Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia.
- Medicine
- JAMA
- 2010
- 161
- PDF
Cognitive functioning and brain magnetic resonance imaging in children with sickle cell disease
- Medicine
- 1996
- 348
- Highly Influential
Silent cerebral infarcts in sickle cell anemia: a risk factor analysis. The Cooperative Study of Sickle Cell Disease.
- Medicine
- Pediatrics
- 1999
- 209
Increased serum-GFAP in patients with severe traumatic brain injury is related to outcome
- Medicine
- Journal of the Neurological Sciences
- 2006
- 169