Plasma gastrin and gastric enterochromaffinlike cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomized rats.

@article{Larsson1986PlasmaGA,
  title={Plasma gastrin and gastric enterochromaffinlike cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomized rats.},
  author={H{\aa}kan Larsson and Enar Carlsson and Hillevi Mattsson and Lars Lundell and Frank Sundler and G W Sundell and Bj{\"o}rn Wallmark and Tetsu Watanabe and Rolf H{\aa}kanson},
  journal={Gastroenterology},
  year={1986},
  volume={90 2},
  pages={391-9}
}
Unoperated female rats were subjected to daily oral treatment with omeprazole (10 or 400 mumol/kg body wt), ranitidine (175 + 175 + 350 mumol/kg body wt), or vehicle and antrectomized rats were treated with omeprazole (400 mumol/kg body wt) or vehicle. After 10 wk of treatment, plasma gastrin levels were high in unoperated rats treated with the high omeprazole dose and with ranitidine, and low in antrectomized controls. Plasma gastrin levels were slightly higher in the low-dose omeprazole group… CONTINUE READING