Plasma folate, related genetic variants, and colorectal cancer risk in EPIC.

  title={Plasma folate, related genetic variants, and colorectal cancer risk in EPIC.},
  author={Simone J P M Eussen and Stein Emil Vollset and Jannicke Igland and Klaus Meyer and Ase Fredriksen and Per Magne Ueland and M. Jenab and Nadia Slimani and Paolo A Boffetta and Kim Overvad and Anne Tj\onneland and Anja Olsen and Francoise Clavel-Chapelon and Marie-Christine Boutron-Ruault and Sophie Morois and C Toffetti Weikert and Tobias Pischon and Jakob P Linseisen and Rudolf Kaaks and Antonia Trichopoulou and Demosthenes Zilis and Michael Katsoulis and Domenico Palli and Franco Berrino and Paolo Vineis and Rosario Tumino and Salvatore Panico and P. H. Peeters and Hendrik Bas Bueno-de-Mesquita and Fr{\"a}nzel J. B. van Duijnhoven and Inger Torhild Gram and Guri Skeie and Eiliv Lund and Carlos A. Gonz{\'a}lez and Carmen Mart{\'i}nez and Miren Dorronsoro and Eva Ardanaz and Carmen Navarro and Laudina Rodr{\'i}guez and Bethany van Guelpen and Richard Palmqvist and Jonas Manjer and Ulrika Ericson and Sheila Anne Bingham and Kay-tee Khaw and Teresa Norat and Elio Riboli},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={19 5},
BACKGROUND A potential dual role of folate in colorectal cancer (CRC) is currently subject to debate. We investigate the associations between plasma folate, several relevant folate-related polymorphisms, and CRC risk within the large European Prospective Investigation into Cancer and Nutrition cohort. METHODS In this nested case-control study, 1,367 incident CRC cases were matched to 2,325 controls for study center, age, and sex. Risk ratios (RR) were estimated with conditional logistic… CONTINUE READING