Plasma fibronectin synthesis in normal and injured humans as determined by stable isotope incorporation.

@article{Thompson1989PlasmaFS,
  title={Plasma fibronectin synthesis in normal and injured humans as determined by stable isotope incorporation.},
  author={Carl I. Thompson and Frank A. Blumenstock and Thomas M. Saba and Paul J. Feustel and Jonathan E. Kaplan and John B. Fortune and Leslie Hough and Virginia Gray},
  journal={The Journal of clinical investigation},
  year={1989},
  volume={84 4},
  pages={1226-35}
}
In humans, plasma fibronectin decreases early after operative injury, burn, or trauma, followed by a rapid restoration with a secondary decline typically observed if such patients become septic. We determined the rate of plasma fibronectin and plasma fibrinogen synthesis in normal subjects and injured patients using a stable isotope incorporation technique with [15N]glycine. During a constant 14-h infusion of [15N]glycine, the enrichment of [15N]glycine in both the free plasma glycine precursor… CONTINUE READING