Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis.

@article{Danesh2005PlasmaFL,
  title={Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis.},
  author={John Danesh and Sarah Lewington and Simon G Thompson and Gordon D. O. Lowe and Rory Collins and John B. Kostis and A. C. Wilson and Aaron R. Folsom and K. K. Wu and Michal Benderly and Uri Goldbourt and Johann Willeit and Stefan Kiechl and John W. G. Yarnell and Peter M. Sweetnam and Peter C. Elwood and Mary Cushman and Bruce M. Psaty and Russell P. Tracy and A. Tybjaerg-hansen and Frits Haverkate and Moniek P. M. de Maat and Francis Gerry R Fowkes and A. J. Lee and Felicity B Smith and Veikko V Salomaa and Kennet Harald and Renata Rasi and Elina M. Vahtera and Pekka Jousilahti and Juha Pekkanen and Ralph B. D'Agostino and William B. Kannel and Peter W. F. Wilson and Geoffrey H. Tofler and Carmen Luisa Arocha-Pi{\~n}ango and A. Rodriguez-Larralde and Elena Nagy and Mercedes Elena Mijares and Ra{\'u}l A Espinosa and E Rodriquez-Roa and Elena Ryder and Mar{\'i}a Diez‐Ewald and Gilberto Campos and Virginia Fern{\'a}ndez and Enrique Torres and Roberto Marchioli and Franco Valagussa and Annika Rosengren and Lars Wilhelmsen and Georgios Lappas and Henry Eriksson and Peter Cremer and Dorothea Nagel and J. David Curb and Beatriz L. Rodr{\'i}guez and Katsuhiko Yano and Jukka T. Salonen and Kristiina Nyyss{\"o}nen and Tomi-Pekka Tuomainen and Bo Hedblad and Peter Lind and Hannelore Loewel and Wolfgang Koenig and Tom W Meade and Jackie A. Cooper and Bianca L. De Stavola and C. Knottenbelt and George J. Miller and Kenneth A. Bauer and Robert D. Rosenberg and S. Sato and Akihiko Kitamura and Yoshihiko Naito and Timo Palosuo and Pierre Ducimetiere and Philippe Amouyel and Dominique Arveiler and Alun E. Evans and Jean Ferri{\`e}res and I Juhan-vague and Annie Bingham and Helmut Schulte and Gerd Assmann and Bernard Cantin and Beno{\^i}t Lamarche and Jean-Pierre Despr{\'e}s and Gilles R. Dagenais and Hugh Tunstall-Pedoe and Mark Woodward and Yoav Ben-Shlomo and George Davey Smith and V. Palmieri and Jeunliang Yeh and Alicja R. Rudnicka and Paul M. Ridker and Francesco Rodeghiero and Alberto Tosetto and James Shepherd and Ian Ford and Michele Robertson and Eric J. Brunner and M J Shipley and Edith J. M. Feskens and Daan Kromhout and Alfred Dickinson and Belinda K Ireland and Kelsey Juzwishin and Stephen Kaptoge and Sarah Lewington and Anis Memon and Nadeem Sarwar and Matthew Walker and Jeremy G. Wheeler and Ian R. White and Angela M. Wood},
  journal={JAMA},
  year={2005},
  volume={294 14},
  pages={
          1799-809
        }
}
CONTEXT Plasma fibrinogen levels may be associated with the risk of coronary heart disease (CHD) and stroke. OBJECTIVE To assess the relationships of fibrinogen levels with risk of major vascular and with risk of nonvascular outcomes based on individual participant data. DATA SOURCES Relevant studies were identified by computer-assisted searches, hand searches of reference lists, and personal communication with relevant investigators. STUDY SELECTION All identified prospective studies… Expand
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  • C. Braybrook
  • Medicine
  • Nature Clinical Practice Cardiovascular Medicine
  • 2006
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Plasma fibrinogen lever and risk of coronary heart disease among Chinese population: a systematic review and meta-analysis.
TLDR
A meta-analysis of prospective studies of plasma fibrinogen level in relation to CHD risk in electronic database of Medline, EMBase, the Cochrane Library and CNKI found that plasma fibinogen levels of patients were significantly higher than control group and may be a risk factor and predictor of CHD. Expand
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References

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TLDR
The published results from these prospective studies are remarkably consistent for each factor, indicating moderate but highly statistically significant associations with CHD, even though mechanisms that might account for these associations are not clear. Expand
Fibrinogen is a predictor of mortality in coronary heart disease patients. The Bezafibrate Infarction Prevention (BIP) Study Group.
TLDR
It is indicated clearly that fibrinogen level is associated with significantly increased mortality in CHD patients and implementation of a standardized measuring method is required to allow assessment of risk inCHD patients on the basis of fibr inogen levels. Expand
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TLDR
Risks of recurrent ischemic stroke and acute coronary events increase linearly with fibrinogen levels, but the relationships are weaker than in some previous population-based studies. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
Although causality cannot be inferred from these data, it is possible that the fibrinogen level plays an important part in the development of stroke and myocardial infarction. Expand
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The age-specific relevance of blood pressure to cause-specific mortality is best assessed by collaborative meta-analysis of individual participant data from the separate prospective studies. MethodsExpand
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