Plasma exchange in polyneuropathy associated with monoclonal gammopathy of undetermined significance.

@article{Dyck1991PlasmaEI,
  title={Plasma exchange in polyneuropathy associated with monoclonal gammopathy of undetermined significance.},
  author={P. Dyck and P. Low and A. Windebank and S. Jaradeh and S. Gosselin and P. Bourque and B. E. Smith and K. Kratz and J. Karnes and B. A. Evans},
  journal={The New England journal of medicine},
  year={1991},
  volume={325 21},
  pages={
          1482-6
        }
}
BACKGROUND Polyneuropathy associated with monoclonal gammopathy of undetermined significance (MGUS) has been treated with plasma exchange, intravenous immune globulin, and chemotherapy, but the effectiveness of these treatments remains uncertain. METHODS We randomly assigned 39 patients with stable or worsening neuropathy and MGUS of the IgG, IgA, or IgM type to receive either plasma exchange twice weekly for three weeks or sham plasma exchange, in a double-blind trial. The patients who… Expand
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