Plasma estrone-sulfate assessment of reduced estrogen production during treatment of metastatic breast carcinoma

@article{Samojlik1982PlasmaEA,
  title={Plasma estrone-sulfate assessment of reduced estrogen production during treatment of metastatic breast carcinoma},
  author={Eugeniusz Samojlik and RichardJ. Santen and Thomas J. Worgul},
  journal={Steroids},
  year={1982},
  volume={39},
  pages={497-507}
}
Highly sensitive and specific estrogen assays are required to monitor the hormonal effects of surgical adrenalectomy or pharmacologic estrogen suppression in postmenopausal women with breast carcinoma. Because the levels of plasma estrone-sulfate are 10-fold higher than its unconjugated counterpart, we developed a radioimmunoassay for estrone-sulfate to quantitate the minimal estrogen concentrations expected under conditions of endocrine gland ablation. After establishing normal ranges, we… CONTINUE READING
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