Plasma endotoxin concentrations in experimental and clinical equine subjects.

  title={Plasma endotoxin concentrations in experimental and clinical equine subjects.},
  author={John F. Fessler and Gerald D. Bottoms and Gordon L. Coppoc and S Gimarc and H S Latshaw and Jillian Noble},
  journal={Equine veterinary journal. Supplement},
Endotoxin (LPS) was quantitated in experimental subjects and in horses with naturally occurring gastrointestinal strangulation obstruction and/or septicaemic diseases to establish the fate of LPS and the clinical usefulness of the Limulus amoebocyte lysate (LAL) assay. The assay was validated for sensitivity (10 pg/ml), recovery (90 to 106 per cent), intra-assay precision (CV = 5.5 per cent) inter-assay precision (CV = 11 per cent), and stability of diluted, heat treated, frozen samples (at… CONTINUE READING

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