Plasma distribution, disappearance half-time, metabolic clearance rate, and degradation of synthetic ovine corticotropin-releasing factor in man.

@article{Nicholson1983PlasmaDD,
  title={Plasma distribution, disappearance half-time, metabolic clearance rate, and degradation of synthetic ovine corticotropin-releasing factor in man.},
  author={Wendell E Nicholson and G S Decherney and Richard V Jackson and C R Debold and Howard D. Uderman and Alison Alexander and Jean Rivier and Wylie Vale and David N. Orth},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1983},
  volume={57 6},
  pages={1263-9}
}
The plasma distribution, disappearance half-time, MCR, and degradation of corticotropin-releasing factor (CRF) were studied in normal men who received a pulse injection of synthetic ovine CRF (oCRF). Graded iv doses of oCRF produced a linear increase in plasma immunoreactive oCRF (IR-oCRF). The calculated total plasma content of IR-oCRF 2 min after injection represented 41.7 +/- 2.5% (mean +/- SE) of the injected dose. The disappearance of IR-oCRF from plasma was characterized by a… CONTINUE READING

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