Plasma disposition of toltrazuril and its metabolites, toltrazuril sulfoxide and toltrazuril sulfone, in rabbits after oral administration.

  title={Plasma disposition of toltrazuril and its metabolites, toltrazuril sulfoxide and toltrazuril sulfone, in rabbits after oral administration.},
  author={M. Kim and Jong-Hwan Lim and Y. Hwang and B. Park and In-Bae Song and H. Yun},
  journal={Veterinary parasitology},
  volume={169 1-2},
  • M. Kim, Jong-Hwan Lim, +3 authors H. Yun
  • Published 2010
  • Biology, Medicine
  • Veterinary parasitology
  • The objective of this study was to evaluate the pharmacokinetic profiles of toltrazuril (TZR), and its major metabolites toltrazuril sulfoxide (TZR x SO) and toltrazuril sulfone (TZR x SO(2)) in rabbits after oral administrations. Rabbits were dosed once with 10 and 20mg/kg TZR via stomach tube with manual restraint. The plasma concentrations of TZR, TZR x SO and TZR x SO(2) were determined by liquid chromatography/mass spectrometry. Plasma concentration-time data after single oral… CONTINUE READING
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