Plasma-derived microparticles for biomarker discovery.

  title={Plasma-derived microparticles for biomarker discovery.},
  author={David M. Smalley and Klaus Ley},
  journal={Clinical laboratory},
  volume={54 3-4},
The field of mass spectrometry-based proteomics has been transformed over the last decade due to advances in technology, sample preparation, bioinformatics, and computational tools. While this has led to a dramatic increase in research related to biomarker discovery, the promise of finding a significant number of new biomarkers has not yet materialized. Current proteomic technology is able to detect and analyze extremely small amounts of proteins (picomole to attomole level), but has difficulty… CONTINUE READING
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