Plasma delivery of retinoic acid to tissues in the rat.

  title={Plasma delivery of retinoic acid to tissues in the rat.},
  author={Sara B Kurlandsky and M. Gamble and Ramugounder Ramakrishnan and William S. Blaner},
  journal={The Journal of biological chemistry},
  volume={270 30},
All-trans-retinoic acid (RA) activates ligand-dependent transcription factors that regulate retinoid-responsive gene expression. It is assumed that all-trans-RA is formed within cells through in situ oxidation of retinol derived from the circulation. However, the circulation contains low levels of all-trans-RA (approximately 0.2-0.7% of that of plasma retinol). Our studies investigated the extent to which plasma all-trans-RA contributes to tissue pools of this retinoid and explored factors… CONTINUE READING