Plasma concentrations of osteopontin, but not thrombin-cleaved osteopontin, are associated with the presence and severity of nephropathy and coronary artery disease in patients with type 2 diabetes mellitus

@inproceedings{Yan2010PlasmaCO,
  title={Plasma concentrations of osteopontin, but not thrombin-cleaved osteopontin, are associated with the presence and severity of nephropathy and coronary artery disease in patients with type 2 diabetes mellitus},
  author={Xiaoxiang Yan and Motoaki Sano and Lin Lu and Wei Wang and Qi Zhang and Ruiyan Zhang and Lingjie Wang and Qiujing Chen and Keiichi Fukuda and Wei Shen},
  booktitle={Cardiovascular diabetology},
  year={2010}
}
BACKGROUND The aim of the present cross-sectional study was to assess possible associations between osteopontin (OPN), and thrombin-cleaved (N-half) OPN, and nephropathy and coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). METHODS Plasma levels of OPN, N-half OPN, and high-sensitivity C-reactive protein (hsCRP) were determined in 301 diabetic patients with (n = 226) or without (n = 75) angiographically documented CAD (luminal diameter narrowing >50%), as well as… CONTINUE READING

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