Plasma concentrations of lamotrigine and its 2-N-glucuronide metabolite during pregnancy in women with epilepsy.

@article{Ohman2008PlasmaCO,
  title={Plasma concentrations of lamotrigine and its 2-N-glucuronide metabolite during pregnancy in women with epilepsy.},
  author={Inger K Ohman and Olof Beck and Sigurd Vitols and Torbjōrn Tomson},
  journal={Epilepsia},
  year={2008},
  volume={49 6},
  pages={1075-80}
}
OBJECTIVE To further characterize pregnancy-induced alterations in the pharmacokinetics of lamotrigine (LTG). METHODS Fifteen women treated with LTG were studied during 17 pregnancies. Complete trough blood samples from all trimesters and baseline > 1 month after delivery were available for 12 pregnancies (Group A), whereas, five contributed with samples only from the third trimester and baseline (Group B). High-performance liquid chromatography (HPLC) was used to determine LTG plasma… CONTINUE READING

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