Plasma concentrations but not serum concentrations of brain-derived neurotrophic factor are related to pro-inflammatory cytokines in patients undergoing major abdominal surgery.

@article{Chimienti2012PlasmaCB,
  title={Plasma concentrations but not serum concentrations of brain-derived neurotrophic factor are related to pro-inflammatory cytokines in patients undergoing major abdominal surgery.},
  author={Guglielmina Chimienti and Anna Mezzapesa and Maria Teresa Rotelli and Luigi G Lupo and Gilda Pepe},
  journal={Clinical biochemistry},
  year={2012},
  volume={45 9},
  pages={631-6}
}
OBJECTIVES To investigate peripheral brain-derived neurotrophic factor (BDNF) concentrations in the perioperative period, their relationship with transforming growth factor-β1 (TGF-β1 tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6) and IL-6 genetics. DESIGN AND METHODS Prospective, observational study. BDNF, TGF-β1, IL-6 and TNF-α were analysed at baseline (T0), 5 h (T1), 24 h (T2) and 5 days (T3) after surgery, in 21 patients. The IL-6 -174 G/C polymorphism was genotyped. RESULTS… CONTINUE READING

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