Plasma concentrations and organ distribution of thiopurines after oral application of azathioprine in mice

@article{Kurowski1991PlasmaCA,
  title={Plasma concentrations and organ distribution of thiopurines after oral application of azathioprine in mice},
  author={Volkhard Kurowski and Heiko Iven},
  journal={Cancer Chemotherapy and Pharmacology},
  year={1991},
  volume={28},
  pages={7-14}
}
The plasma concentrations and tissue distribution of thiopurines were studied in mice after oral administration of 50 mg/kg azathioprine (AZA) using HPLC analysis. Peak concentrations of AZA and three other thiopurine metabolites in plasma [thiouric acid (TUA) >6-mercaptopurine (6-MP)>AZA>8-hydroxy-AZA] were observed as early as 10 min after drug application, thus indicating fast absorption and extensive metabolism of AZA, and were followed by a rapid decline. The extraction of thiopurines from… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Azathioprine. In: Sartorelli AC, John DG (eds) Antineoplastic and immunosuppressive agents. (Handbook of experimental pharmacology

  • GB Elion, GH Hitchings
  • 1975
Highly Influential
5 Excerpts

Disposition of azathioprine metabolites, thiouric acid and 6-mercaptopurine, in renal transplant patients

  • GLC Chan, DM Cannafax, GR Erdmann, RL Simmons
  • Clin Pharmacol Ther
  • 1988
3 Excerpts

HPLC determination of 6-thiouric acid and 6-mercaptopurine in organ transplant patient serum

  • GR Erdmann, GLC Chan, DM Canafax
  • J Liquid Chromatogr
  • 1988
2 Excerpts

Similar Papers

Loading similar papers…