Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease.

@article{Blankenberg2003PlasmaCA,
  title={Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease.},
  author={Stefan S Blankenberg and Hans Jurgen Rupprecht and Odette Poirier and Christoph Bickel and Marek Smieja and Gerd Hafner and Juergen Meyer and François Cambien and Laurence Tiret},
  journal={Circulation},
  year={2003},
  volume={107 12},
  pages={1579-85}
}
BACKGROUND Matrix metalloproteinase (MMP)-9 secretion by macrophages and other inflammatory cells accelerates atherosclerotic progression and destabilizes vulnerable plaque in animal models. However, epidemiological data evaluating the prognostic impact of circulating concentrations and functional genetic variations of MMP-9 are lacking. METHODS AND RESULTS In a prospective study of 1127 patients with documented coronary artery disease, we measured baseline plasma MMP-9 levels and determined… CONTINUE READING
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