Plasma concentrations and behavioral, antinociceptive, and physiologic effects of methadone after intravenous and oral transmucosal administration in cats.

@article{Ferreira2011PlasmaCA,
  title={Plasma concentrations and behavioral, antinociceptive, and physiologic effects of methadone after intravenous and oral transmucosal administration in cats.},
  author={Tatiana Henriques Ferreira and Marlis L. Rezende and Khursheed R. Mama and Susan F. Hudachek and Antonio Jos{\'e} de A. Aguiar},
  journal={American journal of veterinary research},
  year={2011},
  volume={72 6},
  pages={764-71}
}
OBJECTIVE To determine plasma concentrations and behavioral, antinociceptive, and physiologic effects of methadone administered via IV and oral transmucosal (OTM) routes in cats. ANIMALS 8 healthy adult cats. PROCEDURES Methadone was administered via IV (0.3 mg/kg) and OTM (0.6 mg/kg) routes to each cat in a balanced crossover design. On the days of drug administration, jugular catheters were placed in all cats under anesthesia; a cephalic catheter was also placed in cats that received… CONTINUE READING

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