Plasma compatibility of injectables: comparison of intravenous U-74006F, a 21-aminosteroid antioxidant, with Dilantin brand of parenteral phenytoin.

@article{Cox1991PlasmaCO,
  title={Plasma compatibility of injectables: comparison of intravenous U-74006F, a 21-aminosteroid antioxidant, with Dilantin brand of parenteral phenytoin.},
  author={Joanna Cox and Gregory P. Le Sage and Michael A Wynalda and Robert G. Ulrich and Pat Larson and Chin Cheng Su},
  journal={Journal of pharmaceutical sciences},
  year={1991},
  volume={80 4},
  pages={371-5}
}
The 21-aminosteroid antioxidant U-74006F (1) is being developed as an iv injectable agent for the treatment of human CNS trauma and ischemia. Because of its poor water solubility, the plasma compatibility of the parenteral formulation of 1 was evaluated using three models: (I) static solubility, (II) aggregometric, and (III) dynamic flow. The flow model was designed to mimic an iv infusion into the human antecubital vein, which was assumed to have plasma flow of 10 mL/min. Dilantin (phenytoin… CONTINUE READING