Corpus ID: 28305544

Plasma clearance of a new contrast agent, iohexol: a method for the assessment of glomerular filtration rate.

@article{Krutzn1984PlasmaCO,
  title={Plasma clearance of a new contrast agent, iohexol: a method for the assessment of glomerular filtration rate.},
  author={E. Krutz{\'e}n and S. B{\"a}ck and I. Nilsson-ehle and P. Nilsson-ehle},
  journal={The Journal of laboratory and clinical medicine},
  year={1984},
  volume={104 6},
  pages={
          955-61
        }
}
We developed a rapid and precise method for the chemical determination of a new contrast agent, iohexol (N,N'-bis(2,3-dihydroxypropyl)-5-N-(2,3-dihydroxypropyl)-acetamido-2,4, 6-triiodoisophtalamide). Its sensitivity allows the monitoring of plasma concentrations for at least 6 hours after the injection of a single small dose. The elimination rate of iohexol was constant after approximately 90 minutes; plasma clearance in healthy volunteers averaged 127 ml/min. The injected dose was… Expand
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