Plasma citrulline concentration: a surrogate end point for radiation-induced mucosal atrophy of the small bowel. A feasibility study in 23 patients.

@article{Lutgens2004PlasmaCC,
  title={Plasma citrulline concentration: a surrogate end point for radiation-induced mucosal atrophy of the small bowel. A feasibility study in 23 patients.},
  author={L. C. H. W. Lutgens and Nicolaas E P Deutz and Marlies Granzier-Peeters and Regina G. H. Beets-Tan and Dirk K. M. De Ruysscher and John Gueulette and Jack P. M. Cleutjens and Martijn P.F. Berger and Bradly G. Wouters and Maarten F. von Meyenfeldt and Philippe Lambin},
  journal={International journal of radiation oncology, biology, physics},
  year={2004},
  volume={60 1},
  pages={275-85}
}
PURPOSE Plasma citrulline, a nitrogen end product of glutamine metabolism in small-bowel enterocytes, was suggested as a marker of radiation-induced small-bowel epithelial cell loss in mice after single-dose whole-body irradiation. Our objective was to evaluate the feasibility of citrulline as a marker for radiation-induced small-intestinal mucosal atrophy in patients during and after abdominal fractionated radiotherapy. METHODS AND MATERIALS Twenty-three patients were studied weekly during… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…