Plasma cholesterol synthesis using deuterated water in humans: effect of short-term food restriction.

@article{Jones1988PlasmaCS,
  title={Plasma cholesterol synthesis using deuterated water in humans: effect of short-term food restriction.},
  author={Peter J. H. Jones and Angelo M. Scanu and Dale A. Schoeller},
  journal={The Journal of laboratory and clinical medicine},
  year={1988},
  volume={111 6},
  pages={627-33}
}
Our purpose was to develop methods in humans to determine the fractional synthetic rate (FSR) of plasma pool free cholesterol using the rate of deuterium incorporation from body water. The sensitivity of this method was examined by measuring FSR after periods of fasting and feeding. Five healthy men with normal lipoprotein levels were given a prepared diet containing 40% of calories as fat and a polyunsaturated/saturated fatty acid ratio of 0.25 for 8 days, except for day 7 when they were given… CONTINUE READING

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