Plasma-cell homing

@article{Kunkel2003PlasmacellH,
  title={Plasma-cell homing},
  author={Eric J. Kunkel and Eugene C. Butcher},
  journal={Nature Reviews Immunology},
  year={2003},
  volume={3},
  pages={822-829}
}
Recent studies indicate that chemoattractant cytokines (chemokines), together with tissue-specific adhesion molecules, coordinate the migration of antibody-secreting cells (ASCs) from their sites of antigen-driven differentiation in lymphoid tissues to target effector tissues. Developing ASCs downregulate the expression of receptors for lymphoid tissue chemokines and selectively upregulate the expression of chemokine receptors that might target the migration of IgA ASCs to mucosal surfaces, IgG… Expand
Chemoattractants and their receptors in homeostasis and inflammation.
The study of leukocyte migration continues to provide new insights into the regulation of lymphocyte priming in secondary lymphoid organs and effector responses in inflamed tissues. ChemoattractantExpand
Chapter 34 – Lymphocyte Homing: Chemokines and Adhesion Molecules in T cell and IgA Plasma Cell Localization in the Mucosal Immune System
This chapter provides an overview of the tissue-selective lymphocyte trafficking, reviews some of the major homing receptors involved in the intestinal lymphocyte recruitment, and highlights the roleExpand
Tissue Specific Heterogeneity in Effector Immune Cell Response
TLDR
This review has focused on the factors regulating the generation and migration of effector T cells to various tissues along with giving an overview of tissue tropism in B cells. Expand
Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs.
  • J. Cyster
  • Biology, Medicine
  • Annual review of immunology
  • 2005
TLDR
The steps associated with the initiation of adaptive immune responses in secondary lymphoid organs are reviewed, highlighting the roles of chemokines and S1P. Expand
Molecular Determinants Controlling Homeostatic Recirculation and Tissue-Specific Trafficking of Lymphocytes
TLDR
The present understanding of the homeostatic recirculation of naïve lymphocytes through the secondary lymphoid tissues and the specific targeting of antigen-experienced lymphocytes into the effector sites is summarized. Expand
Homing imprinting and immunomodulation in the gut: role of dendritic cells and retinoids.
  • J. Mora
  • Biology, Medicine
  • Inflammatory bowel diseases
  • 2008
TLDR
The present review addresses current understanding of how tissue-specific homing is acquired and modulated on T cells, B cells, and ASC, with a special emphasis on the intestinal mucosa, to offer novel, effective, and more specific therapeutic strategies in IBD. Expand
APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa.
TLDR
It is found that mucosal humoral immunity in APRIL-deficient mice is less persistent than in WT mice, and production of APRIL by inflammation-recruited neutrophils may create plasma cell niches in MALT to sustain a local antibody production. Expand
[Lymphocyte trafficking and immunesurveillance].
TLDR
This review summarizes the present understandings of the mechanisms regulating homeostatic recirculation of naive lymphocytes through the secondary lymphoid tissues and tissue-specific trafficking of antigen-experienced lymphocytes. Expand
Differentiation and homing of IgA-secreting cells
TLDR
The mechanisms involved in the differentiation of IgA-ASCs in mucosal compartments are described, in particular thoseinvolved in the generation of gut-homing IgA -ASCs. Expand
Leukocyte Chemotaxis and Migration
  • 2010
A CRITICAL feature of the innate immune response is the movement of neutrophils and macrophages from one site in the body to another to provide effector functions. These immune cells play a criticalExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 66 REFERENCES
The Intestinal Chemokine Thymus-expressed Chemokine (CCL25) Attracts IgA Antibody-secreting Cells
TLDR
Thymus-expressed chemokine (TECK, CCL25) is a potent and selective chemoattractant for IgA antibody-secreting cells (ASC), efficiently recruiting IgA-producing cells from spleen, Peyer's patches, and mesenteric lymph node, thus helping define and segregate the intestinal immune response. Expand
Cytokine Control of Memory B Cell Homing Machinery1
TLDR
It is shown that CD40 ligand, IL-2, and IL-10 together drive this transition of GC B cells to memory phenotype in vitro, up-regulating memory B cell markers, chemotactic responses to CXC ligand (CXCL)12, CXCL13, and CCL19, and expression of adhesion receptors L-selectin, α4β7, and CLA. Expand
B Lymphocyte Chemotaxis Regulated in Association with Microanatomic Localization, Differentiation State, and B Cell Receptor Engagement
TLDR
Findings show that responsiveness to the chemoattractant SDF-1α is regulated during B lymphocyte activation, and correlates with positioning of B lymphocytes within a secondary lymphoid organ. Expand
Selective chemotaxis of subsets of B lymphocytes from gut-associated lymphoid tissue and its implications for the recruitment of mucosal plasma cells.
TLDR
The data are consistent with the idea that precursors of mucosal IgA plasma cells home to mucosal and exocrine sites in response to a specific chemotactic factor elaborated by local differentiated epithelial cells. Expand
Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position
TLDR
The mechanism of B-cell relocalization in response to antigen is defined, and it is established that cell position in vivo can be determined by the balance of responsiveness to chemoattractants made in separate but adjacent zones. Expand
Chemotactic Responsiveness Toward Ligands for CXCR3 and CXCR4 Is Regulated on Plasma Blasts During the Time Course of a Memory Immune Response1
TLDR
The responsiveness of plasma blasts to these chemokines is restricted to a few days after their emigration from the spleen, indicating a role for these molecules and their cognate receptors in the regulation of plasma blast migration into the bone marrow and/or inflamed tissues. Expand
The Role of Chemokines in the Microenvironmental Control of T versus B Cell Arrest in Peyer's Patch High Endothelial Venules
TLDR
It is shown that T cells roll on most Peyer's patch high endothelial venules (PP-HEVs), but preferentially arrest in segments displaying high levels of luminal secondary lymphoid tissue chemokine (SLC) (6Ckine, Exodus-2, thymus-derived chemotactic agent 4 [TCA-4]). Expand
Developmental Switches in Chemokine Response Profiles during B Cell Differentiation and Maturation
TLDR
Developing B cells undergo dramatic changes in their responses to chemoattractant cytokines (chemokines) and in expression of chemokine receptors, causing their maturation in the marrow and migration to the periphery to be defined. Expand
A Coordinated Change in Chemokine Responsiveness Guides Plasma Cell Movements
TLDR
It is demonstrated that as B cells differentiate into plasma cells they undergo a coordinated change in chemokine responsiveness that regulates their movements in secondary lymphoid organs and promotes lodgment within the bone marrow. Expand
The Cc Chemokine Thymus-Derived Chemotactic Agent 4 (Tca-4, Secondary Lymphoid Tissue Chemokine, 6ckine, Exodus-2) Triggers Lymphocyte Function–Associated Antigen 1–Mediated Arrest of Rolling T Lymphocytes in Peripheral Lymph Node High Endothelial Venules
TLDR
It is concluded that TCA-4 is both required and sufficient for LFA-1 activation on rolling T cells in PLN HEVs, which highlights a hitherto undocumented role for chemokines contained in afferent lymph, which may modulate leukocyte recruitment in draining PLNs. Expand
...
1
2
3
4
5
...