Plasma cell growth fraction using Ki-67 antigen expression identifies a subgroup of multiple myeloma patients displaying short survival within the ISS stage I.

@article{Gastinne2007PlasmaCG,
  title={Plasma cell growth fraction using Ki-67 antigen expression identifies a subgroup of multiple myeloma patients displaying short survival within the ISS stage I.},
  author={Thomas Gastinne and Xavier Leleu and Alain Duhamel and A. S. Moreau and Genevieve Franck and Joris Loup Andrieux and J Lai and Val{\'e}rie Coiteux and Ibrahim Yakoub-Agha and Francis Bauters and J. -L. Harousseau and Marc Zandecki and Thierry Facon},
  journal={European journal of haematology},
  year={2007},
  volume={79 4},
  pages={297-304}
}
The current most powerful prognostic model in Multiple Myeloma (MM) combines beta-2 microglobulin (b2m) with albumin, corresponding to the International Staging System (ISS). However, the prognosis of patients within the ISS stage I (high albumin and low b2m) may vary. Ki-67 is a nuclear protein associated with cell proliferation. We retrospectively evaluated the percentage of bone marrow plasma cells expressing Ki-67 antigen (Ki-67 index) in a series of 174 untreated MM patients at diagnosis… CONTINUE READING

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