Plasma cell differentiation is coupled to division-dependent DNA hypomethylation and gene regulation

@inproceedings{Barwick2016PlasmaCD,
  title={Plasma cell differentiation is coupled to division-dependent DNA hypomethylation and gene regulation},
  author={Benjamin G Barwick and Christopher D Scharer and Alexander P R Bally and Jeremy M Boss},
  booktitle={Nature Immunology},
  year={2016}
}
The epigenetic processes that regulate antibody-secreting plasma cells are not well understood. Here, analysis of plasma cell differentiation revealed DNA hypomethylation of 10% of CpG loci that were overrepresented at enhancers. Inhibition of DNA methylation enhanced plasma cell commitment in a cell-division-dependent manner. Analysis of B cells differentiating in vivo stratified by cell division revealed a fivefold increase in mRNA transcription coupled to DNA hypomethylation. Demethylation… CONTINUE READING