Plasma cell and terminal B-cell differentiation in mantle cell lymphoma mainly occur in the SOX11-negative subtype

@article{RiberaCortada2015PlasmaCA,
  title={Plasma cell and terminal B-cell differentiation in mantle cell lymphoma mainly occur in the SOX11-negative subtype},
  author={Inmaculada Ribera-Cortada and Daniel Mart{\'i}nez and Virginia Amador and Cristina Royo and Alba Navarro and S{\'i}lvia Be{\`a} and Eva Gin{\'e} and Laurence de Leval and Sergio A. Serrano and Andrew Wotherspoon and Dolors Colomer and Antonio Mart{\'i}nez and El{\'i}as Campo},
  journal={Modern Pathology},
  year={2015},
  volume={28},
  pages={1435-1447}
}
Mantle cell lymphoma is a mature lymphoid neoplasm characterized by the t(11;14)(q13;q32) and cyclin D1 overexpression. SOX11 is a transcription factor commonly overexpressed in these tumors but absent in most other mature B-cell lymphomas whose function is not well understood. Experimental studies have shown that silencing of SOX11 in mantle cell lymphoma cells promotes the shift from a mature B cell into an early plasmacytic differentiation phenotype, suggesting that SOX11 may contribute to… CONTINUE READING
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