Plasma binding of 1-butanol, phenol, nitrobenzene and pentachlorophenol in the rainbow trout and rat: a comparative study.

@article{Schmieder1988PlasmaBO,
  title={Plasma binding of 1-butanol, phenol, nitrobenzene and pentachlorophenol in the rainbow trout and rat: a comparative study.},
  author={Patricia K. Schmieder and Thomas R. Henry},
  journal={Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology},
  year={1988},
  volume={91 2},
  pages={
          413-8
        }
}
1. The in vitro binding of 1-butanol, phenol, nitrobenzene, and pentachlorophenol in trout plasma and rat plasma was determined. 2. Binding to rainbow trout plasma proteins agreed within 9% of that observed in rat plasma. 3. Percentage bound to rainbow trout (2-99%) or rat (10-99%) plasma proteins increased as the log octanol/water partition coefficient of the chemicals increased within the Log P 1-3 range, and was suggestive of hydrophobic interactions in binding. 
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