Plasma bilirubin and UGT1A1*28 are not protective factors against first-time myocardial infarction in a prospective, nested case-referent setting.

@article{Ekblom2010PlasmaBA,
  title={Plasma bilirubin and UGT1A1*28 are not protective factors against first-time myocardial infarction in a prospective, nested case-referent setting.},
  author={Kim Ekblom and Stefan L Marklund and J. -H. Jansson and Pia Osterman and G{\"o}ran Hallmans and Lars Weinehall and Johan Hultdin},
  journal={Circulation. Cardiovascular genetics},
  year={2010},
  volume={3 4},
  pages={340-7}
}
BACKGROUND Bilirubin, an effective antioxidant, shows a large variation in levels between individuals and has been positively associated with reduced cardiovascular disease risk. A major reason for the variability is a common promoter polymorphism, UGT1A1*28, which reduces the transcription of the enzyme that conjugates bilirubin, UDP-glucuronosyltransferase 1A1. The aim of the study was to evaluate a possible protective effect of plasma bilirubin and the UGT1A1*28 polymorphism against… CONTINUE READING

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