Plasma antiphospholipid antibody levels in age-related macular degeneration.


PURPOSE To investigate the association of age-related macular degeneration (AMD) with plasma antiphospholipid antibody levels. METHODS This prospective study included 19 patients diagnosed as having dry-type AMD, 23 patients with exudative-type AMD, and 25 control subjects. Venous blood samples of the participants were obtained. Anticardiolipin antibodies (aCL) isotypes IgG and IgM were measured by means of an enzyme-linked immunosorbent assay. Lupus anticoagulant (LA) antibodies were measured by the dilute Russell viper venom time screen test. RESULTS The mean aCL IgG concentration in patients with exudative-type AMD was significantly higher than in patients with dry-type AMD and control subjects. The mean ± SE of aCL IgG levels in patients with exudative-type AMD and dry-type AMD and control subjects was 5.46 ± 1.26; 2.55 ± 0.78; and 0.32 ± 0.1, respectively. The mean aCL IgM levels and LA levels in the 3 groups were not statistically different. CONCLUSIONS Our findings suggest that elevated levels of serum aCL, a risk factor for cardiovascular and cerebrovascular diseases, may be associated with exudative-type AMD.

DOI: 10.1016/j.jcjo.2012.03.016
Citations per Year

301 Citations

Semantic Scholar estimates that this publication has 301 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{zkan2012PlasmaAA, title={Plasma antiphospholipid antibody levels in age-related macular degeneration.}, author={Berna {\"{O}zkan and Levent Karabas and {\"{O}zg{\"{u}l Altıntaş and G{\"{u}lden S{\"{o}nmez Tamer and Nurşen Y{\"{u}ksel and Y S{\"{u}kr{\"{u} Cağlar}, journal={Canadian journal of ophthalmology. Journal canadien d'ophtalmologie}, year={2012}, volume={47 3}, pages={264-8} }