Plasma angiopoietin-1, angiopoietin-2 and Tie-2 in breast and prostate cancer: a comparison with VEGF and Flt-1.

@article{Caine2003PlasmaAA,
  title={Plasma angiopoietin-1, angiopoietin-2 and Tie-2 in breast and prostate cancer: a comparison with VEGF and Flt-1.},
  author={Graham J Caine and Andrew D. Blann and Paul S Stonelake and Peter A. Ryan and Gregory Y. H. Lip},
  journal={European journal of clinical investigation},
  year={2003},
  volume={33 10},
  pages={883-90}
}
BACKGROUND Angiogenesis is essential for tumour growth and metastasis, and is coordinated by several classes of growth factors mediating their effect through receptors linked, in turn, to tyrosine kinase. These growth factors include angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF), which act through receptors Flt-1 and Tie-2. MATERIALS AND METHODS In order to further determine abnormalities in levels of Ang-1, Ang-2, Tie-2, sFlt-1 and VEGF in human… CONTINUE READING