Plasma androgens, IGF-1, body size, and prostate cancer risk: a synthetic review

@article{Kaaks2000PlasmaAI,
  title={Plasma androgens, IGF-1, body size, and prostate cancer risk: a synthetic review},
  author={Rudolf Kaaks and Annie Lukanova and Britta Sommersberg},
  journal={Prostate Cancer and Prostatic Diseases},
  year={2000},
  volume={3},
  pages={157-172}
}
We present a review of the epidemiological evidence for relations of prostate cancer risk to circulating total and bioavailable androgens, to alterations in the metabolism of insulin-like growth factor-1 (IGF-1), and to anthropometric indices of longitudinal growth (body stature) and overweight. In addition, we review the physiological inter-relationships between insulin, growth hormone/IGF-1 axis, and sex steroid metabolism, as well as the associations of bioavailable sex steroid levels with… CONTINUE READING
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