Plasma and urine pharmacokinetics of free and of short-chain carnitine after administration of carnitine in man.

@article{Segre1988PlasmaAU,
  title={Plasma and urine pharmacokinetics of free and of short-chain carnitine after administration of carnitine in man.},
  author={Giorgio Segre and Elettra Bianchi and Marcello Corsi and Stefania D'Iddio and Orlando Ghirardi and Franco Maccari},
  journal={Arzneimittel-Forschung},
  year={1988},
  volume={38 12},
  pages={1830-4}
}
To 6 healthy volunteers 30 mg/kg of L-carnitine (1,3-hydroxy-4-N-trimethylamino-butyrate) were injected intravenously and plasma levels (mumol/l) of free and short-chain carnitine were determined at different times between 0.033 and 24 h. The urinary excretion of L-carnitine and short-chain carnitine in 24 h was also measured. After a period of wash-out the subjects received 100 mg/kg of L-carnitine orally and plasma levels were determined between 0.5 and 24 h. The urinary excretion of L… CONTINUE READING

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