Plasma and urinary excretion kinetics of oral baclofen in healthy subjects

@article{Wuis2004PlasmaAU,
  title={Plasma and urinary excretion kinetics of oral baclofen in healthy subjects},
  author={E. Wuis and M. Dirks and E. Termond and T. Vree and E. Kleijn},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={37},
  pages={181-184}
}
SummaryBaclofen, a centrally acting muscle relaxant, is used in the treatment of spasticity. Its pharmacokinetics has been derived from plasma and urine data in four healthy subjects, whose renal function was simultaneously measured.After oral administration of a single 40 mg dose, baclofen was mainly excreted unchanged by the kidney, 69 (14) %. The half-life, calculated from extended least squares modelling (ELSMOS) both of plasma and urine data was 6.80 (0.68) h, which is longer than reported… Expand
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TLDR
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