Plasma and synovial fluid concentrations of diclofenac sodium and its major hydroxylated metabolites during long-term treatment of rheumatoid arthritis

@article{Fowler2004PlasmaAS,
  title={Plasma and synovial fluid concentrations of diclofenac sodium and its major hydroxylated metabolites during long-term treatment of rheumatoid arthritis},
  author={P. D. Fowler and M. Shadforth and P. Crook and V. John},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={25},
  pages={389-394}
}
SummaryPlasma and synovial fluid concentrations of diclofenac sodium and its principal hydroxylated metabolites have been measured in sixteen rheumatoid patients on chronic therapy to investigate possible reasons for the drug's extended duration of action despite its apparent short elimination half-life in plasma. Diclofenac was detected in synovial fluid 2 h after dosing but at a lower level than in plasma. Thereafter synovial fluid concentrations remained relatively constant through to 11 h… Expand
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Paper Mentions

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  • 22
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  • 144
  • Highly Influenced
  • PDF
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  • 12
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  • 102
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 17 REFERENCES
The pharmacokinetics of diclofenac sodium in patients with active rheumatoid disease
  • 16
Characterization of salicylate binding to synovial fluid and plasma protein in patients with rheumatoid arthritis
  • 6
The influence of food on the absorption of diclofenac after single and multiple oral doses
  • 47
Pharmacological properties of diclofenac sodium and its metabolites.
  • 217
Diclofenac sodium (Voltaren) and naproxen in the treatment of rheumatoid arthritis: a comparative double-blind study.
  • 21
Factors influencing the pharmacokinetics of diclofenac sodium
  • PhD-thesis,
  • 1982
Action of sodic diclofenac on enzymes, dialines and prostaglandins of synovial fluid in rheumatoid arthritis; Abstract 228
  • Proceedings of the XV th International Congress of Rheumatology,
  • 1981
...
1
2
...