Plasma and salivary pharmacokinetics of caffeine in man
@article{Newton2004PlasmaAS, title={Plasma and salivary pharmacokinetics of caffeine in man}, author={Ronald Newton and L. J. Broughton and Margareta Lind and P. J. Morrison and Howard J. Rogers and I. D. Bradbrook}, journal={European Journal of Clinical Pharmacology}, year={2004}, volume={21}, pages={45-52} }
SummaryPlasma and salivary caffeine concentrations were measured by gas-liquid chromatography in 6 healthy caffeine-free volunteers following oral administration of 50, 300, 500 and 750 mg caffeine. Caffeine was also given to a single subject intravenously in doses of 300, 500 and 750 mg. Caffeine was rapidly absorbed and was completely available at all doses. The apparent first-order elimination rate constant decreased linearly with dose and was 0.163±0.081 h−1 for 50 mg and 0.098±0.027 h−1…
137 Citations
Comparative pharmacokinetics of caffeine in young and elderly men
- Medicine, BiologyJournal of Pharmacokinetics and Biopharmaceutics
- 2005
It appears that most aspects of the pharmacokinetic behavior of caffeine are very similar in young and elderly men, and the first-pass metabolism observed in rats following the peroral administration of caffeine does not occur in either human group studied here.
Interrelations between plasma caffeine concentrations and neurobehavioural effects in healthy volunteers: model analysis using NONMEM
- Psychology, MedicineBiopharmaceutics & drug disposition
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These results provided the first suggestive evidence that caffeine effects on psychomotor performance occur after some time delay relative to changes in plasma caffeine concentration.
A Study of Caffeine and Its Metabolites in Human Body Fluids.
- Medicine
- 1986
Results indicated that salivary caffeine clearance measurements might provide an accurate means of assessing the extent of hepato-cellular dysfunction, and pharmacologically significant concentrations of caffeine and its metabolites were detected in samples of maternal serum, cord blood and breast milk.
Caffeine and paraxanthine HPLC assay for CYP1A2 phenotype assessment using saliva and plasma.
- Medicine, BiologyBiomedical chromatography : BMC
- 2010
The assay developed is a robust, simple and precise technique to measure caffeine and paraxanthine in saliva and plasma of healthy volunteers after a single oral dose of caffeine.
Caffeine Use in Sports, Pharmacokinetics in Man, and Cellular Mechanisms of Action
- Biology, MedicineCritical reviews in food science and nutrition
- 2005
Evidence from in vitro studies provides a wealth of different cellular actions that could potentially contribute to the observed effects of caffeine in humans in vivo, although a variable degree of contribution cannot be readily discounted on the basis of experimental data.
Low dose caffeine as a salivary tracer for the determination of gastric water emptying in fed and fasted state: A MRI validation study
- MedicineEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
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Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives
- Medicine, BiologyEuropean Journal of Clinical Pharmacology
- 2004
Caffeine clearance, previously reported to be a specific marker of cytochrome P-448 activity in man, is decreased by chronic OCS use, which suggests that OCS may cause significant impairment of this enzyme activity as assessed in vivo.
Caffeine and paraxanthine pharmacokinetics in the rabbit: Concentration and product inhibition effects
- Medicine, BiologyJournal of Pharmacokinetics and Biopharmaceutics
- 2005
Results were consistent with the hypothesis that at least two farms of cytochrome “P-450” mediate the metabolism of C in the rabbit, and exhibited dose-independent pharmacokinetics for C, while the clearances of type I animals were dose-dependent (lower clearances at higher doses).
Effects of time-release caffeine containing supplement on metabolic rate, glycerol concentration and performance.
- Biology, MedicineJournal of sports science & medicine
- 2015
TR-CAF and CAF showed distinct pharmacokinetics yielding modest effects on reaction time, yet did not alter glycerol concentration, metabolic measures, or other performance measures over an 8-hour period following ingestion.
A Pharmacometric Approach to Investigate the Impact of Methylxanthine Abstinence and Caffeine Consumption on CYP1A2 Activity
- BiologyDrug Metabolism and Disposition
- 2013
There was no difference in the mean (95% confidence interval) total apparent caffeine clearance (CL) between the methylxanthine abstinence (MA) periods, and the decrease in CL in the no MA period among HCC appears to be due to alternative caffeine elimination pathways, rather than CYP1A2.
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