Plasma and intracellular pharmacokinetic-pharmacodynamic analysis of mycophenolic acid in de novo kidney transplant patients.

@article{Thi2015PlasmaAI,
  title={Plasma and intracellular pharmacokinetic-pharmacodynamic analysis of mycophenolic acid in de novo kidney transplant patients.},
  author={Minh Thuan Nguyen Thi and M. Hussein Mourad and Arnaud Capron and Flora Musuamba Tshinanu and M F Vincent and Pierre E Wallemacq},
  journal={Clinical biochemistry},
  year={2015},
  volume={48 6},
  pages={401-5}
}
OBJECTIVES Little is known about the correlation between the inosine-monophosphate dehydrogenase (IMPDH) activity and mycophenolic acid (MPA) concentrations in peripheral-blood-mononuclear cells (PBMCs), where the drug is acting. The aim of this study was to analyze the relationship between plasma or PBMC MPA levels, as pharmacokinetic (PK) markers, and the intracellular IMPDH enzyme activity, as a pharmacodynamic (PD) biomarker, in kidney transplantation. DESIGN AND METHODS Forty de novo… CONTINUE READING
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