Plasma and interstitial glucose dynamics after intravenous glucose injection: evaluation of the single-compartment glucose distribution assumption in the minimal models.

@article{Regittnig1999PlasmaAI,
  title={Plasma and interstitial glucose dynamics after intravenous glucose injection: evaluation of the single-compartment glucose distribution assumption in the minimal models.},
  author={Werner Regittnig and Zlatko Trajanoski and Hans J{\"o}rg Leis and Martin Ellmerer and Andrea Wutte and Gerald Sendlhofer and Lukas Schaupp and Gwendolyn Brunner and Paul F Wach and Thomas R. Pieber},
  journal={Diabetes},
  year={1999},
  volume={48 5},
  pages={1070-81}
}
Recent experimental evidence suggests that estimates of glucose effectiveness (S(G)) from the minimal model of unlabeled glucose disappearance (Cold-MM) are in error. The single-compartment glucose distribution assumption embedded in the model has been indicated as a possible source of error. In this study, to directly examine the single-compartment assumption, we measured plasma and interstitial glucose concentrations after intravenous glucose injection. Additionally, we compared the accuracy… CONTINUE READING

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