Plasma and cerebrospinal fluid population pharmacokinetics of temozolomide in malignant glioma patients.


PURPOSE Scarce information is available on the brain penetration of temozolomide (TMZ), although this novel methylating agent is mainly used for the treatment of malignant brain tumors. The purpose was to assess TMZ pharmacokinetics in plasma and cerebrospinal fluid (CSF) along with its inter-individual variability, to characterize covariates and to explore… (More)


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