Plasma and cerebrospinal fluid amino acid patterns in hepatic encephalopathy

@article{Cascino2005PlasmaAC,
  title={Plasma and cerebrospinal fluid amino acid patterns in hepatic encephalopathy},
  author={Antonia Cascino and Carlo Cangiano and Franco Fiaccadori and Florio Ghinelli and Manuela Merli and Guido Pelosi and Oliviero Riggio and Filippo Rossi Fanelli and Daria Sacchini and M. Stortoni and Livio Capocaccia},
  journal={Digestive Diseases and Sciences},
  year={2005},
  volume={27},
  pages={828-832}
}
Plasma and cerebrospinal fluid amino acid levels were measured in 12 cirrhotic patients in grade 0 hepatic encephalopathy and 17 in grade 3–4 hepatic encephalopathy. In 5 of these patients amino acid determinations were performed during the evolution of the encephalopathy. No correlation was found between the degree of hepatic encephalopathy and the plasma amino acid imbalance. In the CSF of cirrhotic patients without encephalopathy, a significant increase was found in nearly all amino acids… 
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The findings that serotoninergic turnover is exquisitely and selectively sensitive to the degree of porto-systemic shunting and hyperammonemia suggest a role for serotonin in early neuropsychiatric symptoms of HE.
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