Plasma and cerebrospinal fluid amino acid patterns in hepatic encephalopathy

  title={Plasma and cerebrospinal fluid amino acid patterns in hepatic encephalopathy},
  author={Antonia Cascino and Carlo Cangiano and Franco Fiaccadori and Florio Ghinelli and Manuela Merli and Guido Pelosi and Oliviero Riggio and Filippo Rossi Fanelli and Daria Sacchini and M. Stortoni and Livio Capocaccia},
  journal={Digestive Diseases and Sciences},
Plasma and cerebrospinal fluid amino acid levels were measured in 12 cirrhotic patients in grade 0 hepatic encephalopathy and 17 in grade 3–4 hepatic encephalopathy. In 5 of these patients amino acid determinations were performed during the evolution of the encephalopathy. No correlation was found between the degree of hepatic encephalopathy and the plasma amino acid imbalance. In the CSF of cirrhotic patients without encephalopathy, a significant increase was found in nearly all amino acids… 
Aromatic and branched-chain amino acids in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy
Concentrations of the branched-chain amino acids (BCAAs) valine, leucine, and isoleucine and the aromatic amino acids (AAAs) phenylalanine and tyrosine were measured in three areas of dissected brain
Cerebral blood flow and plasma free tryptophan in cirrhotics with and without hepatic encephalopathy
It is concluded that CBF could have some implications in SHE, although its relevance is still unclear, and the negative correlation between CBF and f TRP prompts further investigation concerning the relationships between plasma fTRP, brain serotonin, cerebral metabolism and blood flow in the development of brain derangement during cirrhosis.
Monoamines and metabolites in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy
Findings show that selective alterations of catecholamine and 5-HT systems are involved in human HE and therefore, they may play an important role in the pathogenesis of certain neurological symptoms associated with this encephalopathy.
Modification in CSF specific gravity in acutely decompensated cirrhosis and acute on chronic liver failure independent of encephalopathy, evidences for an early blood-CSF barrier dysfunction in cirrhosis
In patients with acute decompensation of cirrhosis, and those with ACLF, CSF specific gravity is modified compared to both stable cirrhotic patients and healthy controls, suggesting that blood-CSF barrier impairment is manifest even in absence of overt hepatic encephalopathy.
Serotonin Brain Circuits with a Focus on Hepatic Encephalopathy
The findings that serotoninergic turnover is exquisitely and selectively sensitive to the degree of porto-systemic shunting and hyperammonemia suggest a role for serotonin in early neuropsychiatric symptoms of HE.
Regional alterations of dopamine and its metabolites in rat brain following portacaval anastomosis
Increased DA turnover thus appears to relate to early neuropsychiatric and extrapyramidal symptoms of PSE, and did not worsen at coma states of P SE.
Neurotransmitter receptor alterations in hepatic encephalopathy: a review.
ATP-binding cassette transporters expression in rats with cirrhosis and hepatic encephalopathy.


The effect of normalization of plasma amino acids on hepatic encephalopathy in man.
Whereas amino acid infusion appears to be a valuable, efficacious way of providing nutrition in treating hepatic encephalopathy in patients with cirrhosis and acute deterioration and coma, other means of therapy such as plasms "laundering" appear to be necessary in Patients with fulminant hepatitis.
Plasma amino acids imbalance in patients with liver disease
A very good correlation with the grade of the mental disorder was found with the ratios free tryptophan/phenylalanine-tyrosine-methionine-valine-leucine-isoleucine and freetryptophans/branched-chain amino acids.
Alterations in Plasma and CSF Amino Acids, Amines and Metabolites in Hepatic Coma
The results indicate that the altered levels of aromatic and branched chain amino acids, octopamine and PEA in plasma and CSF correlate well with the development of HE and that correction of the plasma amino acid abnormalities improves encephalopathy simultaneously with correction of neurotransmitter derangements in CSF.
Prevalence of subclinical hepatic encephalopathy in cirrhotics and relationship to plasma amino acid imbalance
It is concluded that a considerable proportion of clinically normal cirrhotics have neuropsychological deficits and the severity of impairment may be related to the plasma amino acid imbalance, namely to an increased passage of tryptophan across the blood-brain barrier.
Parenteral nutrition and coma therapy with amino acids in hepatic failure.
In 103 cirrhotic patients, the effects of 4 amino acid mixtures, glucose, and a diet containing 40 g of protein were investigated and Amino acids given intravenously in a dose of 50 g/day were investigated.
The role of plasma amino acids in hepatic encephalopathy.
The results suggest that manipulation and normalization of plasma amino acids in animals with hepatic failure may be efficacious in providing adequate nutrition while minimizing hepatic encephalopathy.
Selective amino acid solutions in hepatic encephalopathy treatment
Clinical, laboratory and EEG examinations in a preliminary experiment showed that the best effect was obtained by the combined treatment with amino acid solutions and lactulose.
A longitudinal study of tryptophan involvement in hepatic coma.