Plasma and brain levels of glutamate and pyroglutamate after oral monosodium glutamate to rats.

@article{Caccia1982PlasmaAB,
  title={Plasma and brain levels of glutamate and pyroglutamate after oral monosodium glutamate to rats.},
  author={Silvio Caccia and Silvio Garattini and Pietro Ghezzi and Maur{\'i}zio Zanini},
  journal={Toxicology letters},
  year={1982},
  volume={10 2-3},
  pages={
          169-75
        }
}
Plasma and brain levels of pyroglutamate (Py), a compound connected with the pathway of glutamate (GA) metabolism, were measured in rats after oral administration of monosodium glutamate (MSG) or Py. Oral MSG (1 g/kg) was followed by only a small rise in plasma Py levels. No increase of Py or GA brain levels was observed in these experimental conditions. Oral administration of Py (0.05, 0.5 and 1 g/kg) resulted in a marked dose-dependent increase of plasma Py, but no increase of plasma or brain… CONTINUE READING
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