Plasma and blood assay of xanthine and hypoxanthine by gas chromatography-mass spectrometry: physiological variations in humans.

@article{LartigueMattei1990PlasmaAB,
  title={Plasma and blood assay of xanthine and hypoxanthine by gas chromatography-mass spectrometry: physiological variations in humans.},
  author={C. Lartigue-Mattei and Jean Louis Chabard and H. Bargnoux and J. Petit and J. A. Berger and Jean Michel Ristori and Jeanine Bussiere and Pierre Catilina and M J Catilina},
  journal={Journal of chromatography},
  year={1990},
  volume={529 1},
  pages={
          93-101
        }
}
Studies on the purine-pyrimidine metabolism (2)--Effects of sample preparation and diet on the concentrations of oxypurines in blood and urine.
TLDR
The evaluation of the sampling procedures showed that the levels of plasma oxypurines were overestimated by more than 15% for Hyp and 35% for Xan when heparinized plasma separation was delayed for 5 minutes after sampling, and dietary influences on purine-pyrimidine metabolites should also be considered for the accurate measurement of their concentrations in blood and urine.
Kinetics of allopurinol and its metabolite oxypurinol after oral administration of allopurinol alone or associated with benzbromarone in man. Simultaneous assay of hypoxanthine and xanthine by gas chromatography‐mass spectrometry
TLDR
The action of the two agents may be synergistic and not antagonistic, a pharmacological justification for the therapeutic use of this drug association and its role on the blood uric acid lowering action is complex.
Binding of Xanthine Oxidase to Glycosaminoglycans Limits Inhibition by Oxypurinol*
TLDR
The results reveal that GAG immobilization of XO in both HS6B and cell models substantially limits oxypurinol inhibition of Xo, an event that has important relevance for the use of pyrazolo inhibitors ofXO in clinical situations where XO and its products may play a pathogenic role.
Nitrite reductase activity of rat and human xanthine oxidase, xanthine dehydrogenase, and aldehyde oxidase: evaluation of their contribution to NO formation in vivo.
TLDR
This work characterized NO formation by rat and human XO/XD and AO, the first characterization of human enzymes, and the results support the employment of rat liver enzymes as suitable models of the human counterparts.
Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis.
TLDR
Observations indicate that as intracellular folates decrease in HeLa cells, due to decreased extracellular reduced folate, or loss of RFC function, pemetrexed inhibition of GARFT increases, and data support the concept that the contribution to pemberrexed activity by inhibition ofGARFT, particularly at low folate levels, is a contributing factor to drug activity.
Alteration of soluble adhesion molecules during aging and their modulation by calorie restriction
TLDR
The findings suggest that the altered expressions of sAMs may be due to increased oxidative stress with advanced age and that these increases were prevented by CR through its antioxidative action.
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