Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease.

  title={Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease.},
  author={Richard P. Mayeux and M. X. Tang and Diane M. Jacobs and Jennifer M Manly and Karen Bell and Clark A. Merchant and Scott A. Small and Yaakov Stern and Henryk M. Wiśniewski and Pankaj D. Mehta},
  journal={Annals of neurology},
  volume={46 3},
Mutations in the amyloid precursor protein and presenilin 1 and 2 genes result in elevated plasma levels of the amyloid beta-peptide species terminating at amino acid residue 42 (A beta1-42). In a longitudinal study of unrelated elderly individuals, those who subsequently developed Alzheimer's disease had higher plasma levels of A beta1-42 at entry than did those who remained free of dementia. The results indicate that elevated plasma levels of the released A beta peptide A beta1-42 may be… CONTINUE READING

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