Plasma amino acid profiles are associated with insulin, C-peptide and adiponectin levels in type 2 diabetic patients

@inproceedings{Nakamura2014PlasmaAA,
  title={Plasma amino acid profiles are associated with insulin, C-peptide and adiponectin levels in type 2 diabetic patients},
  author={Hironori K Nakamura and H Jinzu and Keisuke Nagao and Yoshinori Noguchi and Noriko Shimba and Hiroshi Miyano and Tsuguhiro Watanabe and Kunitoshi Iseki},
  booktitle={Nutrition & Diabetes},
  year={2014}
}
Objectives:Plasma-free amino acid (PFAA) profiles have been associated with a future risk of developing diabetes or cardiovascular disease in nondiabetic subjects. These PFAA alterations might predominantly result from the metabolic shift caused by insulin resistance and visceral fat deposition. The variety of PFAA profiles within diabetic subjects is not well researched. In this study, we focused on type 2 diabetic subjects and examined the association between PFAA profiles and insulin- and… CONTINUE READING

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Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
AlanineNo subtypeProline
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
ProlineNo subtypeAlanine
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
AlanineNo subtypeTyrosine
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
TyrosineNo subtypeAlanine
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Amino AcidsChemical structure ofAlanine
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Plasma amino acid profiles are associated with insulin , C - peptide and adiponectin levels in type 2 diabetic patients .
Plasma amino acid profiles are associated with insulin , C - peptide and adiponectin levels in type 2 diabetic patients .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Amino AcidsChemical structure ofGlutamic Acid
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
In the group of diabetic patients with hyperinsulinemia , the amino acid levels were significantly increased , which generally demonstrated good concordance with insulin - related markers and adiponectin levels .
The PFAA profiles in diabetic patients were strongly associated with hyperinsulinemia and hypoadiponectinemia , which might become risk evaluation factors for the development of cardiovascular diseases .
In the group of diabetic patients with hyperinsulinemia , the amino acid levels were significantly increased , which generally demonstrated good concordance with insulin - related markers and adiponectin levels .
The PFAA profiles in diabetic patients were strongly associated with hyperinsulinemia and hypoadiponectinemia , which might become risk evaluation factors for the development of cardiovascular diseases .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
ProlineNo subtypeTyrosine
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
TyrosineNo subtypeProline
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
Although strong correlations between PFAAs and glucose - related markers were not observed , several amino acids ( branched - chain amino acids , tryptophan , alanine , tyrosine , glutamate and proline ) and PFAA indices that evaluate visceral obesity were highly correlated with insulin - related markers and adiponectin ( P<0.001 ) .
The plasma concentrations of 21 amino acids ; glucose - related markers including glucose , hemoglobin A1c ( HbA1c ) , glycoalbumin and 1,5-anhydroglucitol ; insulin - related markers including insulin , C - peptide , and the homeostasis model assessment of insulin resistance ; and adipocytokines including adiponectin and leptin were determined .
The plasma concentrations of 21 amino acids ; glucose - related markers including glucose , hemoglobin A1c ( HbA1c ) , glycoalbumin and 1,5-anhydroglucitol ; insulin - related markers including insulin , C - peptide , and the homeostasis model assessment of insulin resistance ; and adipocytokines including adiponectin and leptin were determined .
The plasma concentrations of 21 amino acids ; glucose - related markers including glucose , hemoglobin A1c ( HbA1c ) , glycoalbumin and 1,5-anhydroglucitol ; insulin - related markers including insulin , C - peptide , and the homeostasis model assessment of insulin resistance ; and adipocytokines including adiponectin and leptin were determined .
The plasma concentrations of 21 amino acids ; glucose - related markers including glucose , hemoglobin A1c ( HbA1c ) , glycoalbumin and 1,5-anhydroglucitol ; insulin - related markers including insulin , C - peptide , and the homeostasis model assessment of insulin resistance ; and adipocytokines including adiponectin and leptin were determined .
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