Plasma amino acid concentrations in normal adults administered aspartame in capsules or solution: lack of bioequivalence.

@article{Stegink1987PlasmaAA,
  title={Plasma amino acid concentrations in normal adults administered aspartame in capsules or solution: lack of bioequivalence.},
  author={Lewis D. Stegink and L. J. Jr. Filer and Edward F. Bell and Ekhard E. Ziegler},
  journal={Metabolism: clinical and experimental},
  year={1987},
  volume={36 5},
  pages={
          507-12
        }
}
  • Lewis D. Stegink, L. J. Jr. Filer, +1 author Ekhard E. Ziegler
  • Published 1987
  • Chemistry, Medicine
  • Metabolism: clinical and experimental
  • Some clinical studies require administration of test compounds in capsules to assure that the compound cannot be distinguished from a placebo. This raises the question of whether the pharmacokinetic responses produced by capsule administration are similar to values obtained when test compounds are ingested in solution. To test this, plasma phenylalanine and aspartate concentrations were compared in ten normal subjects ingesting 3 g aspartame in solution and in capsules in a balanced Latin… CONTINUE READING