Plasma alpha-glutathione S-transferase: a sensitive indicator of hepatocellular damage during polymicrobial sepsis.

@article{Koo2000PlasmaAS,
  title={Plasma alpha-glutathione S-transferase: a sensitive indicator of hepatocellular damage during polymicrobial sepsis.},
  author={Douglas J Koo and Mian Zhou and Irshad H. Chaudry and Ping Wang},
  journal={Archives of surgery},
  year={2000},
  volume={135 2},
  pages={198-203}
}
HYPOTHESIS Since studies have found the liver enzyme alpha-glutathione S-transferase (alphaGST) to be a marker of hepatic injury after hemorrhagic shock, alphaGST also may serve as a sensitive indicator of hepatocellular damage during the early stage of polymicrobial sepsis. DESIGN, INTERVENTIONS, AND MAIN OUTCOME MEASURES Male adult rats were subjected to the cecal ligation and puncture (CLP) model of polymicrobial sepsis or sham operation, followed by fluid resuscitation with isotonic… CONTINUE READING
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