Plasma alkaline phosphatase is elevated in Alzheimer's disease and inversely correlates with cognitive function.

@article{Kellett2011PlasmaAP,
  title={Plasma alkaline phosphatase is elevated in Alzheimer's disease and inversely correlates with cognitive function.},
  author={Katherine A B Kellett and Jonathan Williams and Emma R.L.C. Vardy and Anthony D. Smith and Nigel M Hooper},
  journal={International journal of molecular epidemiology and genetics},
  year={2011},
  volume={2 2},
  pages={
          114-21
        }
}
Alkaline phosphatase is present on neuronal membranes and plasma alkaline phosphatase activity increases in brain injury and cerebrovascular disease, suggesting that plasma alkaline phosphatase may partly reflect neuronal loss. As neuronal loss occurs in Alzheimer's disease (AD), we hypothesised that alterations in plasma alkaline phosphatase activity may correlate with cognitive impairment. Plasma alkaline phosphatase activity was measured in the longitudinal Oxford Project to Investigate… CONTINUE READING
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